ea0070aep795 | Reproductive and Developmental Endocrinology | ECE2020
Devillers Marie
, Petit Florence
, Giton Frank
, François Charlotte
, Juricek Ludmila
, Coumoul Xavier
, Magre Solange
, Cohen-Tannoudji Joëlle
, Guigon Celine
Background: In females, timing of puberty and fertility require estradiol (E2) action at the infantile and late juvenilestages and are tightly influenced by environmental cues. A regulator of intra-ovarian E2 synthesis during reproductive life is the aryl hydrocarbon receptor (AhR). However, its action on E2 synthesis and its capacity to mediate the effect of endocrine disrupting chemicals (EDC)s has not been thoroughly evaluated during the prepubertal period.<p class="abs...